Myelin Basic Protein as a Novel Genetic Risk Factor in Rheumatoid Arthritis—A Genome-Wide Study Combined with Immunological Analyses

Chikashi Terao, Koichiro Ohmura, Masaki Katayama, Meiko Takahashi, Miki Kokubo, Gora Diop, Yoshinobu Toda, Natsuki Yamamoto, Human Disease Genomics Working Group, Rheumatoid Arthritis (RA) Clinical and Genetic Study Consortium, Reiko Shinkura, Masakazu Shimizu, Ivo Gut, Simon Heath, Inga Melchers, Toshiaki Manabe, Mark Lathrop, Tsuneyo Mimori, Ryo Yamada and Fumihiko Matsuda

PLOS ONE, 2011, vol. 6, issue 6, 1-10

Abstract: Rheumatoid arthritis (RA) is a major cause of adult chronic inflammatory arthritis and a typical complex trait. Although several genetic determinants have been identified, they account for only a part of the genetic susceptibility. We conducted a genome-wide association study of RA in Japanese using 225,079 SNPs genotyped in 990 cases and 1,236 controls from two independent collections (658 cases and 934 controls in collection1; 332 cases and 302 controls in collection2), followed by replication studies in two additional collections (874 cases and 855 controls in collection3; 1,264 cases and 948 controls in collection4). SNPs showing p

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0020457

DOI: 10.1371/journal.pone.0020457

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