Scaling Behavior of Human Locomotor Activity Amplitude: Association with Bipolar Disorder

Premananda Indic, Paola Salvatore, Carlo Maggini, Stefano Ghidini, Gabriella Ferraro, Ross J Baldessarini and Greg Murray

PLOS ONE, 2011, vol. 6, issue 5, 1-8

Abstract: Scale invariance is a feature of complex biological systems, and abnormality of multi-scale behaviour may serve as an indicator of pathology. The hypothalamic suprachiasmatic nucleus (SCN) is a major node in central neural networks responsible for regulating multi-scale behaviour in measures of human locomotor activity. SCN also is implicated in the pathophysiology of bipolar disorder (BD) or manic-depressive illness, a severe, episodic disorder of mood, cognition and behaviour. Here, we investigated scaling behaviour in actigraphically recorded human motility data for potential indicators of BD, particularly its manic phase. A proposed index of scaling behaviour (Vulnerability Index [VI]) derived from such data distinguished between: [i] healthy subjects at high versus low risk of mood disorders; [ii] currently clinically stable BD patients versus matched controls; and [iii] among clinical states in BD patients.

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0020650

DOI: 10.1371/journal.pone.0020650

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