Genomic Risk Profiling of Ischemic Stroke: Results of an International Genome-Wide Association Meta-Analysis

James F Meschia, Andrew Singleton, Michael A Nalls, Stephen S Rich, Pankaj Sharma, Luigi Ferrucci, Mar Matarin, Dena G Hernandez, Kerra Pearce, Thomas G Brott, Robert D Brown, John Hardy and Bradford B Worrall

PLOS ONE, 2011, vol. 6, issue 9, 1-7

Abstract: Introduction: Familial aggregation of ischemic stroke derives from shared genetic and environmental factors. We present a meta-analysis of genome-wide association scans (GWAS) from 3 cohorts to identify the contribution of common variants to ischemic stroke risk. Methods: This study involved 1464 ischemic stroke cases and 1932 controls. Cases were genotyped using the Illumina 610 or 660 genotyping arrays; controls, with Illumina HumanHap 550Kv1 or 550Kv3 genotyping arrays. Imputation was performed with the 1000 Genomes European ancestry haplotypes (August 2010 release) as a reference. A total of 5,156,597 single-nucleotide polymorphisms (SNPs) were incorporated into the fixed effects meta-analysis. All SNPs associated with ischemic stroke (P

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0023161

DOI: 10.1371/journal.pone.0023161

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