Analysis of Factors Lowering Sensitivity of Interferon-γ Release Assay for Tuberculosis

Nguyen Thi Le Hang, Luu Thi Lien, Nobuyuki Kobayashi, Takuro Shimbo, Shinsaku Sakurada, Pham Huu Thuong, Le Thi Hong, Do Bang Tam, Minako Hijikata, Ikumi Matsushita, Nguyen Van Hung, Kazue Higuchi, Nobuyuki Harada and Naoto Keicho

PLOS ONE, 2011, vol. 6, issue 8, 1-8

Abstract: Background: Imperfect sensitivity of interferon-γ release assay (IGRA) is a potential problem to detect tuberculosis. We made a thorough investigation of the factors that can lead to false negativity of IGRA. Methods: We recruited 543 patients with new smear-positive pulmonary tuberculosis in Hanoi, Viet Nam. At diagnosis, peripheral blood was collected and IGRA (QuantiFERON-TB Gold In-Tube) was performed. Clinical and epidemiological information of the host and pathogen was collected. The test sensitivity was calculated and factors negatively influencing IGRA results were evaluated using a logistic regression model in 504 patients with culture-confirmed pulmonary tuberculosis. Results: The overall sensitivity of IGRA was 92.3% (95% CI, 89.6%–94.4%). The proportions of IGRA-negative and -indeterminate results were 4.8% (95% CI, 3.1%–7.0%) and 3.0% (95% CI, 1.7%–4.9%). Age increased by year, body mass index

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0023806

DOI: 10.1371/journal.pone.0023806

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