H1-Antihistamine Up-Dosing in Chronic Spontaneous Urticaria: Patients' Perspective of Effectiveness and Side Effects – A Retrospective Survey Study

Karsten Weller, Claudia Ziege, Petra Staubach, Knut Brockow, Frank Siebenhaar, Karoline Krause, Sabine Altrichter, Martin K Church and Marcus Maurer

PLOS ONE, 2011, vol. 6, issue 9, 1-6

Abstract: Background: The guidelines recommend that first line treatment of chronic spontaneous urticaria should be second generation non-sedating H1-antihistamines with a positive recommendation against the use of old sedating first generation antihistamines. If standard dosing is not effective, increasing the dosage up to four-fold is recommended. The objective of this study was to obtain the chronic spontaneous urticaria-patient perspective on the effectiveness and unwanted effects of H1-antihistamines in standard and higher doses. Methodology/Principal Findings: This was a questionnaire based survey, initially completed by 368 individuals. 319 (248 female, 71 male, median age 42 years) had a physician-confirmed diagnosis of chronic spontaneous urticaria and were included in the results. Participants believed standard doses (manufacturers recommended dose) of second generation antihistamines to be significantly (P

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0023931

DOI: 10.1371/journal.pone.0023931

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