The De-Ubiquitinylating Enzyme, USP2, Is Associated with the Circadian Clockwork and Regulates Its Sensitivity to Light

Heather Dehlin Scoma, Monica Humby, Geetha Yadav, Qingjiong Zhang, Joseph Fogerty and Joseph C Besharse

PLOS ONE, 2011, vol. 6, issue 9, 1-14

Abstract: We have identified a novel component of the circadian clock that regulates its sensitivity to light at the evening light to dark transition. USP2 (Ubiquitin Specific Protease 2), which de-ubiquitinylates and stabilizes target proteins, is rhythmically expressed in multiple tissues including the SCN. We have developed a knockout model of USP2 and found that exposure to low irradiance light at ZT12 increases phase delays of USP2−/− mice compared to wildtype. We additionally show that USP2b is in a complex with several clock components and regulates the stability and turnover of BMAL1, which in turn alters the expression of several CLOCK/BMAL1 controlled genes. Rhythmic expression of USP2 in the SCN and other tissues offers a new level of control of the clock machinery through de-ubiqutinylation and suggests a role for USP2 during circadian adaptation to environmental day length changes.

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0025382

DOI: 10.1371/journal.pone.0025382

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