Genetic Variations in Plasma Circulating DNA of HBV-Related Hepatocellular Carcinoma Patients Predict Recurrence after Liver Transplantation

Jie Hu, Zheng Wang, Jia Fan, Zhi Dai, Yi-Feng He, Shuang-Jian Qiu, Xiao-Wu Huang, Jian Sun, Yong-Sheng Xiao, Kang Song, Ying-Hong Shi, Qi-Man Sun, Xin-Rong Yang, Guo-Ming Shi, Lei Yu, Guo-Huan Yang, Zhen-Bin Ding, Qiang Gao, Zhao-You Tang and Jian Zhou

PLOS ONE, 2011, vol. 6, issue 10, 1-10

Abstract: Background: Recurrence prediction of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT) present a great challenge because of a lack of biomarkers. Genetic variations play an important role in tumor development and metastasis. Methods: Oligonucleotide microarrays were used to evaluate the genetic characteristics of tumor DNA in 30 HBV-related HCC patients who were underwent LT. Recurrence-related single-nucleotide polymorphism were selected, and their prognostic value was assessed and validated in two independent cohorts of HCC patients (N = 102 and N = 77), using pretransplant plasma circulating DNA. Prognostic significance was assessed by Kaplan-Meier survival estimates and log-rank tests. Multivariate analyses were performed to evaluate prognosis-related factors. Results: rs894151 and rs12438080 were significantly associated with recurrence (P = .003 and P = .004, respectively). Multivariate analyses demonstrated that the co-index of the 2 SNPs was an independent prognostic factor for recurrence (P = .040). Similar results were obtained in the third cohort (N = 77). Furthermore, for HCC patients (all the 3 cohorts) exceeding Milan criteria, the co-index was a prognostic factor for recurrence and survival (P

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0026003

DOI: 10.1371/journal.pone.0026003

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