Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma

Verena Bihrer, Oliver Waidmann, Mireen Friedrich-Rust, Nicole Forestier, Simone Susser, Jörg Haupenthal, Martin Welker, Ying Shi, Jan Peveling-Oberhag, Andreas Polta, Michael von Wagner, Heinfried H Radeke, Christoph Sarrazin, Jörg Trojan, Stefan Zeuzem, Bernd Kronenberger and Albrecht Piiper

PLOS ONE, 2011, vol. 6, issue 10, 1-7

Abstract: Background: MicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including hepatocellular carcinoma (HCC). Elevated concentrations of miR-21 have also been found in sera or plasma from patients with malignancies, rendering it an interesting candidate as serum/plasma marker for malignancies. Here we correlated serum miR-21 levels with clinical parameters in patients with different stages of chronic hepatitis C virus infection (CHC) and CHC-associated HCC. Methodology/Principal Findings: 62 CHC patients, 29 patients with CHC and HCC and 19 healthy controls were prospectively enrolled. RNA was extracted from the sera and miR-21 as well as miR-16 levels were analyzed by quantitative real-time PCR; miR-21 levels (normalized by miR-16) were correlated with standard liver parameters, histological grading and staging of CHC. The data show that serum levels of miR-21 were elevated in patients with CHC compared to healthy controls (P

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0026971

DOI: 10.1371/journal.pone.0026971

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