Are Helicobacter Pylori and Other Helicobacter Species Infection Associated with Human Biliary Lithiasis? A Meta-Analysis

Di Zhou, Yong Zhang, Wei Gong, Sayid Omar Mohamed, Henry Ogbomo, Xuefeng Wang, Yingbin Liu and Zhiwei Quan

PLOS ONE, 2011, vol. 6, issue 11, 1-8

Abstract: Background: Since the isolation of Helicobacter species in biliary system, a hypothetical question was raised about the role of these agents in the development of cholelithiasis. This meta-analysis is to explore the association between the Helicobacter infection and biliary lithiasis. Methodology/Principal Findings: A systematic literature search was performed to identify all eligible articles. Meta-analysis which was carried out using odds ratio and random effect model, 95% confidence intervals for odds ratio was calculated. Quantitative assessment of heterogeneity was explored by chi-square test with significance set at P value 0.10 and was measured using I2 statistic. Eighteen studies published between 1998 and 2011 were finally eligible for meta-analysis. H. Pylori, H. Bilis, H. Hepaticus, H. Pullorum and H. Ganmani were studied. With heterogeneity (I2 = 69.5%, P

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0027390

DOI: 10.1371/journal.pone.0027390

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