The Effect of hOGG1 Ser326Cys Polymorphism on Cancer Risk: Evidence from a Meta-Analysis

Bingbing Wei, You Zhou, Zhuoqun Xu, Bo Xi, Huan Cheng, Jun Ruan, Ming Zhu, Qiang Hu, Qiang Wang, Zhirong Wang, Zhiqiang Yan, Ke Jin, Deqi Zhou, Feng Xuan, Xing Huang, Jianfeng Shao and Peng Lu

PLOS ONE, 2011, vol. 6, issue 11, 1-7

Abstract: Background: Human oxoguanine glycosylase 1 (hOGG1) in base excision repair (BER) pathway plays a vital role in DNA repair. Numerous epidemiological studies have evaluated the association between hOGG1 Ser326Cys polymorphism and the risk of cancer. However, the results of these studies on the association remain conflicting. To derive a more precise estimation of the association, we conducted a meta-analysis. Methodology/Principal Findings: A comprehensive search was conducted to identify the eligible studies of hOGG1 Ser326Cys polymorphism and cancer risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. We found that the hOGG1 Ser326Cys polymorphism was significantly associated with overall cancer risk (Cys/Cys vs. Ser/Ser: OR = 1.19, 95%CI = 1.09–1.30, P

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0027545

DOI: 10.1371/journal.pone.0027545

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