The Influence of Deleterious Mutations on Adaptation in Asexual Populations

Xiaoqian Jiang, Zhao Xu, Jingjing Li, Youyi Shi, Wenwu Wu and Shiheng Tao

PLOS ONE, 2011, vol. 6, issue 11, 1-8

Abstract: We study the dynamics of adaptation in asexual populations that undergo both beneficial and deleterious mutations. In particular, how the deleterious mutations affect the fixation of beneficial mutations was investigated. Using extensive Monte Carlo simulations, we find that in the “strong-selection weak mutation (SSWM)” regime or in the “clonal interference (CI)” regime, deleterious mutations rarely influence the distribution of “selection coefficients of the fixed mutations (SCFM)”; while in the “multiple mutations” regime, the accumulation of deleterious mutations would lead to a decrease in fitness significantly. We conclude that the effects of deleterious mutations on adaptation depend largely on the supply of beneficial mutations. And interestingly, the lowest adaptation rate occurs for a moderate value of selection coefficient of deleterious mutations.

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0027757

DOI: 10.1371/journal.pone.0027757

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