Effect of Temperature on Cystic Fibrosis Lung Disease and Infections: A Replicated Cohort Study

Joseph M Collaco, John McGready, Deanna M Green, Kathleen M Naughton, Christopher P Watson, Timothy Shields, Scott C Bell, Claire E Wainwright and Garry R. Cutting 3 for the ACFBAL Study Group

PLOS ONE, 2011, vol. 6, issue 11, 1-7

Abstract: Background: Progressive lung disease accounts for the majority of morbidity and mortality observed in cystic fibrosis (CF). Beyond secondhand smoke exposure and socio-economic status, the effect of specific environmental factors on CF lung function is largely unknown. Methods: Multivariate regression was used to assess correlation between specific environmental factors, the presence of pulmonary pathogens, and variation in lung function using subjects enrolled in the U.S. CF Twin and Sibling Study (CFTSS: n = 1378). Significant associations were tested for replication in the U.S. CF Foundation Patient Registry (CFF: n = 16439), the Australian CF Data Registry (ACFDR: n = 1801), and prospectively ascertained subjects from Australia/New Zealand (ACFBAL: n = 167). Results: In CFTSS subjects, the presence of Pseudomonas aeruginosa (OR = 1.06 per °F; p

Date: 2011
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027784 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 27784&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0027784

DOI: 10.1371/journal.pone.0027784

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().