The Heritability of Amyotrophic Lateral Sclerosis in a Clinically Ascertained United States Research Registry

Thomas S Wingo, David J Cutler, Nicole Yarab, Crystal M Kelly and Jonathan D Glass

PLOS ONE, 2011, vol. 6, issue 11, 1-5

Abstract: Background: The genetic basis of amyotrophic lateral sclerosis (ALS) is not entirely clear. While there are families with rare highly penetrant mutations in Cu/Zn superoxide dismutase 1 and several other genes that cause apparent Mendelian inheritance of the disease, most ALS occurs in families without another affected individual. However, twin studies suggest that all ALS has a substantial genetic basis. Herein, we estimate the genetic contribution to ALS in a clinically ascertained case series from the United States. Methodology/Principal Findings: We used the database of the Emory ALS Center to ascertain individuals with ALS along with their family histories to determine the concordance among parents and offspring for the disease. We found that concordance for all parent–offspring pairs was low (

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0027985

DOI: 10.1371/journal.pone.0027985

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