Gaining Greater Insight into HCV Emergence in HIV-Infected Men Who Have Sex with Men: The HEPAIG Study

Christine Larsen, Marie-Laure Chaix, Yann Le Strat, Annie Velter, Anne Gervais, Isabelle Aupérin, Laurent Alric, Xavier Duval, Patrick Miailhes, Corinne Pioche, Stanislas Pol, Lionel Piroth, Elisabeth Delarocque-Astagneau and for the steering committee of the HEPAIG Study

PLOS ONE, 2011, vol. 6, issue 12, 1-9

Abstract: Objectives: The HEPAIG study was conducted to better understand Hepatitis C virus (HCV) transmission among human immuno-deficiency (HIV)-infected men who have sex with men (MSM) and assess incidence of HCV infection among this population in France. Methods and Results: Acute HCV infection defined by anti-HCV or HCV ribonucleic acid (RNA) positivity within one year of documented anti-HCV negativity was notified among HIV-infected MSM followed up in HIV/AIDS clinics from a nationwide sampling frame. HIV and HCV infection characteristics, HCV potential exposures and sexual behaviour were collected by the physicians and via self-administered questionnaires. Phylogenetic analysis of the HCV-NS5B region was conducted. Conclusions: This study emphasizes the role of multiple unprotected sexual practices and recreational drugs use during sex in the HCV emergence in HIV-infected MSM. It becomes essential to adapt prevention strategies and inform HIV-infected MSM with recent acute HCV infection on risk of re-infection and on risk-reduction strategies.

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0029322

DOI: 10.1371/journal.pone.0029322

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