Safety Issues of Long-Term Glucose Load in Patients on Peritoneal Dialysis—A 7-Year Cohort Study

Hon-Yen Wu, Kuan-Yu Hung, Tao-Min Huang, Fu-Chang Hu, Yu-Sen Peng, Jenq-Wen Huang, Shuei-Liong Lin, Yung-Ming Chen, Tzong-Shinn Chu, Tun-Jun Tsai and Kwan-Dun Wu

PLOS ONE, 2012, vol. 7, issue 1, 1-7

Abstract: Background: Effects of long-term glucose load on peritoneal dialysis (PD) patient safety and outcomes have seldom been reported. This study demonstrates the influence of long-term glucose load on patient and technique survival. Methods: We surveyed 173 incident PD patients. Long-term glucose load was evaluated by calculating the average dialysate glucose concentration since initiation of PD. Risk factors were assessed by fitting Cox's models with repeatedly measured time-dependent covariates. Results: We noted that older age, higher glucose concentration, and lower residual renal function (RRF) were significantly associated with a worse patient survival. We found that female gender, absence of diabetes, lower glucose concentration, use of icodextrin, higher serum high density lipoprotein cholesterol, and higher RRF were significantly associated with a better technique survival. Conclusions: Long-term glucose load predicted mortality and technique failure in chronic PD patients. These findings emphasize the importance of minimizing glucose load in PD patients.

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0030337

DOI: 10.1371/journal.pone.0030337

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