Effectiveness of Terbutaline Pump for the Prevention of Preterm Birth. A Systematic Review and Meta-Analysis

Laura M Gaudet, Kavita Singh, Laura Weeks, Becky Skidmore, Alexander Tsertsvadze and Mohammed T Ansari

PLOS ONE, 2012, vol. 7, issue 2, 1-10

Abstract: Background: Subcutaneous terbutaline (SQ terbutaline) infusion by pump is used in pregnant women as a prolonged (beyond 48–72 h) maintenance tocolytic following acute treatment of preterm contractions. The effectiveness and safety of this maintenance tocolysis have not been clearly established. We aimed to systematically evaluate the effectiveness and safety of subcutaneous (SQ) terbutaline infusion by pump for maintenance tocolysis. Methodology/Principal Findings: MEDLINE, EMBASE, CINAHL, the Cochrane Library, the Centre for Reviews and Dissemination databases, post-marketing surveillance data and grey literature were searched up to April 2011 for relevant experimental and observational studies. Conclusions/Significance: Although evidence suggests that pump therapy may be beneficial as maintenance tocolysis, our confidence in its validity and reproducibility is low, suggesting that its use should be limited to the research setting. Concerns regarding safety of therapy persist.

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0031679

DOI: 10.1371/journal.pone.0031679

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