A Replication Study of the Association between Rheumatoid Arthritis and Deletion of the Late Cornified Envelope Genes LCE3B and LCE3C

Judith G M Bergboer, Maša Umićević-Mirkov, Jaap Fransen, Martin den Heijer, Barbara Franke, Piet L C M van Riel, Joost Schalkwijk, Marieke J H Coenen and on behalf of the Nijmegen Biomedical Study principal Investigators

PLOS ONE, 2012, vol. 7, issue 2, 1-5

Abstract: Objective: Two recent studies, in a Spanish and a Chinese population, point to an association between rheumatoid arthritis (RA) risk and the deletion of the Late Cornified Envelope (LCE) 3B and 3C genes (LCE3C_LCE3B-del), a known risk factor for psoriasis. We aimed to replicate these studies in a large Dutch cohort. Methods: 1039 RA cases and 759 controls were genotyped for LCE3C_LCE3B-del. Association analysis was performed for the complete cohort and after stratification for the serologic markers anti-cyclic citrullinated peptide and rheumatoid factor. A meta-analysis was performed combining our data with the Spanish and Chinese datasets, resulting in an analysis including 2466 RA cases and 2438 controls. Results: In the Dutch cohort we did not observe a significant association of LCE3C_LCE3B-del (p = 0.093) with RA risk. A stratified analysis for the serologic positive and negative group did not show an association between the genetic variant and disease risk, either. The meta-analysis, however, confirmed a significant association (p

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0032045

DOI: 10.1371/journal.pone.0032045

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