Ischemic Preconditioning in the Animal Kidney, a Systematic Review and Meta-Analysis

Kimberley E Wever, Theo P Menting, Maroeska Rovers, J Adam van der Vliet, Gerard A Rongen, Rosalinde Masereeuw, Merel Ritskes-Hoitinga, Carlijn R Hooijmans and Michiel Warlé

PLOS ONE, 2012, vol. 7, issue 2, 1-10

Abstract: Ischemic preconditioning (IPC) is a potent renoprotective strategy which has not yet been translated successfully into clinical practice, in spite of promising results in animal studies. We performed a unique systematic review and meta-analysis of animal studies to identify factors modifying IPC efficacy in renal ischemia/reperfusion injury (IRI), in order to enhance the design of future (clinical) studies. An electronic literature search for animal studies on IPC in renal IRI yielded fifty-eight studies which met our inclusion criteria. We extracted data for serum creatinine, blood urea nitrogen and histological renal damage, as well as study quality indicators. Meta-analysis showed that IPC reduces serum creatinine (SMD 1.54 [95%CI 1.16, 1.93]), blood urea nitrogen (SMD 1.42 [95% CI 0.97, 1.87]) and histological renal damage (SMD 1.12 [95% CI 0.89, 1.35]) after IRI as compared to controls. Factors influencing IPC efficacy were the window of protection (

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0032296

DOI: 10.1371/journal.pone.0032296

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