Distinguishing Type 2 Diabetes from Type 1 Diabetes in African American and Hispanic American Pediatric Patients

Nancy Keller, Suruchi Bhatia, Jeanah N Braden, Ginny Gildengorin, Jameel Johnson, Rachel Yedlin, Teresa Tseng, Jacquelyn Knapp, Nicole Glaser, Paula Jossan, Shawn Teran, Erinn T Rhodes and Janelle A Noble

PLOS ONE, 2012, vol. 7, issue 3, 1-7

Abstract: Objective: To test the hypothesis that clinical observations made at patient presentation can distinguish type 2 diabetes (T2D) from type 1 diabetes (T1D) in pediatric patients aged 2 to 18. Subjects and Methods: Medical records of 227 African American and 112 Hispanic American pediatric patients diagnosed as T1D or T2D were examined to compare parameters in the two diseases. Age at presentation, BMI z-score, and gender were the variables used in logistic regression analysis to create models for T2D prediction. Results: The regression-based model created from African American data had a sensitivity of 92% and a specificity of 89%; testing of a replication cohort showed 91% sensitivity and 93% specificity. A model based on the Hispanic American data showed 92% sensitivity and 90% specificity. Similarities between African American and Hispanic American patients include: (1) age at onset for both T1D and T2D decreased from the 1980s to the 2000s; (2) risk of T2D increased markedly with obesity. Racial/ethnic-specific observations included: (1) in African American patients, the proportion of females was significantly higher than that of males for T2D compared to T1D (p

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0032773

DOI: 10.1371/journal.pone.0032773

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