A Common SMAD7 Variant Is Associated with Risk of Colorectal Cancer: Evidence from a Case-Control Study and a Meta-Analysis

Qibin Song, Beibei Zhu, Weiguo Hu, Liming Cheng, Hongyun Gong, Bin Xu, Xiawen Zheng, Li Zou, Rong Zhong, Shengyu Duan, Wei Chen, Rui Rui, Jing Wu and Xiaoping Miao

PLOS ONE, 2012, vol. 7, issue 3, 1-8

Abstract: Background: A common genetic variant, rs4939827, located in SMAD7, was identified by two recent genome-wide association (GWA) studies to be strongly associated with the risk of colorectal cancer (CRC). However, the following replication studies yielded conflicting results. Method and Findings: We conducted a case-control study of 641 cases and 1037 controls in a Chinese population and then performed a meta-analysis, integrating our and published data of 34313 cases and 33251 controls, to clarify the relationship between rs4939827 and CRC risk. In our case-control study, the dominant model was significant associated with increased CRC risk [Odds Ratio (OR) = 1.46; 95% confidence interval (95% CI), 1.19–1.80]. The following meta-analysis further confirmed this significant association for all genetic models but with significant between-study heterogeneity (all P for heterogeneity

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0033318

DOI: 10.1371/journal.pone.0033318

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