Enhanced Interleukin-1 Activity Contributes to Exercise Intolerance in Patients with Systolic Heart Failure

Benjamin W Van Tassell, Ross A Arena, Stefano Toldo, Eleonora Mezzaroma, Tania Azam, Ignacio M Seropian, Keyur Shah, Justin Canada, Norbert F Voelkel, Charles A Dinarello and Antonio Abbate

PLOS ONE, 2012, vol. 7, issue 3, 1-10

Abstract: Background: Heart failure (HF) is a complex clinical syndrome characterized by impaired cardiac function and poor exercise tolerance. Enhanced inflammation is associated with worsening outcomes in HF patients and may play a direct role in disease progression. Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that becomes chronically elevated in HF and exerts putative negative inotropic effects. Methods and Results: We developed a model of IL-1β-induced left ventricular (LV) dysfunction in healthy mice that exhibited a 32% reduction in LV fractional shortening (P

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0033438

DOI: 10.1371/journal.pone.0033438

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