Tuberculosis in HIV-Negative and HIV-Infected Patients in a Low-Incidence Country: Clinical Characteristics and Treatment Outcomes

Lukas Fenner, Sebastien Gagneux, Jean-Paul Janssens, Jan Fehr, Matthias Cavassini, Matthias Hoffmann, Enos Bernasconi, Jacques Schrenzel, Thomas Bodmer, Erik C Böttger, Peter Helbling, Matthias Egger and for the Swiss HIV Cohort and Molecular Epidemiology of Tuberculosis Study Groups

PLOS ONE, 2012, vol. 7, issue 3, 1-5

Abstract: Background: In Switzerland and other developed countries, the number of tuberculosis (TB) cases has been decreasing for decades, but HIV-infected patients and migrants remain risk groups. The aim of this study was to compare characteristics of TB in HIV-negative and HIV-infected patients diagnosed in Switzerland, and between coinfected patients enrolled and not enrolled in the national Swiss HIV Cohort Study (SHCS). Methods and Findings: All patients diagnosed with culture-confirmed TB in the SHCS and a random sample of culture-confirmed cases reported to the national TB registry 2000–2008 were included. Outcomes were assessed in HIV-infected patients and considered successful in case of cure or treatment completion. Ninety-three SHCS patients and 288 patients selected randomly from 4221 registered patients were analyzed. The registry sample included 10 (3.5%) coinfected patients not enrolled in the SHCS: the estimated number of HIV-infected patients not enrolled in the SHCS but reported to the registry 2000–2008 was 146 (95% CI 122–173). Coinfected patients were more likely to be from sub-Saharan Africa (51.5% versus 15.8%, P

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0034186

DOI: 10.1371/journal.pone.0034186

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