Global DNA Hypomethylation in Peripheral Blood Leukocytes as a Biomarker for Cancer Risk: A Meta-Analysis

Hae Dong Woo and Jeongseon Kim

PLOS ONE, 2012, vol. 7, issue 4, 1-8

Abstract: Background: Good biomarkers for early detection of cancer lead to better prognosis. However, harvesting tumor tissue is invasive and cannot be routinely performed. Global DNA methylation of peripheral blood leukocyte DNA was evaluated as a biomarker for cancer risk. Methods: We performed a meta-analysis to estimate overall cancer risk according to global DNA hypomethylation levels among studies with various cancer types and analytical methods used to measure DNA methylation. Studies were systemically searched via PubMed with no language limitation up to July 2011. Summary estimates were calculated using a fixed effects model. Results: The subgroup analyses by experimental methods to determine DNA methylation level were performed due to heterogeneity within the selected studies (p

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0034615

DOI: 10.1371/journal.pone.0034615

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