Optimal Estimation of Ion-Channel Kinetics from Macroscopic Currents

Wei Wang, Feng Xiao, Xuhui Zeng, Jing Yao, Ming Yuchi and Jiuping Ding

PLOS ONE, 2012, vol. 7, issue 4, 1-12

Abstract: Markov modeling provides an effective approach for modeling ion channel kinetics. There are several search algorithms for global fitting of macroscopic or single-channel currents across different experimental conditions. Here we present a particle swarm optimization(PSO)-based approach which, when used in combination with golden section search (GSS), can fit macroscopic voltage responses with a high degree of accuracy (errors within 1%) and reasonable amount of calculation time (less than 10 hours for 20 free parameters) on a desktop computer. We also describe a method for initial value estimation of the model parameters, which appears to favor identification of global optimum and can further reduce the computational cost. The PSO-GSS algorithm is applicable for kinetic models of arbitrary topology and size and compatible with common stimulation protocols, which provides a convenient approach for establishing kinetic models at the macroscopic level.

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0035208

DOI: 10.1371/journal.pone.0035208

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