1,2-Octanediol, a Novel Surfactant, for Treating Head Louse Infestation: Identification of Activity, Formulation, and Randomised, Controlled Trials

Ian F Burgess, Peter N Lee, Katrina Kay, Ruth Jones and Elizabeth R Brunton

PLOS ONE, 2012, vol. 7, issue 4, 1-11

Abstract: Background: Interest in developing physically active pediculicides has identified new active substances. The objective was to evaluate a new treatment for clinical efficacy. Methods and Findings: We describe the selection of 1,2-octanediol as a potential pediculicide. Clinical studies were community based. The main outcome measure was no live lice, after two treatments, with follow up visits over 14 days. Conclusions: 1,2-octanediol was found to eliminate head louse infestation. It is believed to disrupt the insect's cuticular lipid, resulting in dehydration. The alcohol free mousse is more acceptable exhibiting significantly fewer adverse reactions. Trial registrations: Controlled-Trials.com ISRCTN66611560, ISRCTN91870666, ISRCTN28722846

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0035419

DOI: 10.1371/journal.pone.0035419

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