Bronchial Responsiveness Is Related to Increased Exhaled NO (FENO) in Non-Smokers and Decreased FENO in Smokers

Andrei Malinovschi, Christer Janson, Marieann Högman, Giovanni Rolla, Kjell Torén, Dan Norbäck and Anna-Carin Olin

PLOS ONE, 2012, vol. 7, issue 4, 1-7

Abstract: Rationale: Both atopy and smoking are known to be associated with increased bronchial responsiveness. Fraction of nitric oxide (NO) in the exhaled air (FENO), a marker of airways inflammation, is decreased by smoking and increased by atopy. NO has also a physiological bronchodilating and bronchoprotective role. Objectives: To investigate how the relation between FENO and bronchial responsiveness is modulated by atopy and smoking habits. Methods: Exhaled NO measurements and methacholine challenge were performed in 468 subjects from the random sample of three European Community Respiratory Health Survey II centers: Turin (Italy), Gothenburg and Uppsala (both Sweden). Atopy status was defined by using specific IgE measurements while smoking status was questionnaire-assessed. Main Results: Increased bronchial responsiveness was associated with increased FENO levels in non-smokers (p = 0.02) and decreased FENO levels in current smokers (p = 0.03). The negative association between bronchial responsiveness and FENO was seen only in the group smoking less

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0035725

DOI: 10.1371/journal.pone.0035725

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