Sequencing by Hybridization of Long Targets

Yu Qin, Tobias M Schneider and Michael P Brenner

PLOS ONE, 2012, vol. 7, issue 5, 1-6

Abstract: Sequencing by Hybridization (SBH) reconstructs an n-long target DNA sequence from its biochemically determined l-long subsequences. In the standard approach, the length of a uniformly random sequence that can be unambiguously reconstructed is limited to due to repetitive subsequences causing reconstruction degeneracies. We present a modified sequencing method that overcomes this limitation without the need for different types of biochemical assays and is robust to error.

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0035819

DOI: 10.1371/journal.pone.0035819

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