Second-Line Antiretroviral Therapy in a Workplace and Community-Based Treatment Programme in South Africa: Determinants of Virological Outcome

Victoria Johnston, Katherine Fielding, Salome Charalambous, Mildred Mampho, Gavin Churchyard, Andrew Phillips and Alison D Grant

PLOS ONE, 2012, vol. 7, issue 5, 1-11

Abstract: Background: As antiretroviral treatment (ART) programmes in resource-limited settings mature, more patients are experiencing virological failure. Without resistance testing, deciding who should switch to second-line ART can be difficult. The consequences for second-line outcomes are unclear. In a workplace- and community-based multi-site programme, with 6-monthly virological monitoring, we describe outcomes and predictors of viral suppression on second-line, protease inhibitor-based ART. Methods: We used prospectively collected clinic data from patients commencing first-line ART between 1/1/03 and 31/12/08 to construct a study cohort of patients switched to second-line ART in the presence of a viral load (VL) ≥400 copies/ml. Predictors of VL

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0036997

DOI: 10.1371/journal.pone.0036997

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