IL-6-174 G/C and -572 C/G Polymorphisms and Risk of Alzheimer’s Disease

Hui-Ping Qi, Zheng-Yi Qu, Shu-Rong Duan, Shu-Qin Wei, Shi-Rong Wen and Sheng Bi

PLOS ONE, 2012, vol. 7, issue 6, 1-6

Abstract: Associations between interleukin 6 (IL-6) polymorphisms and Alzheimer’s disease (AD) remain controversial and ambiguous. The aim of this meta-analysis is to explore more precise estimations for the relationship between IL-6-174 G/C and -572 C/G polymorphisms and risk for AD. Electronic searches for all publications in databases PubMed and EMBASE were conducted on the associations between IL-6 polymorphisms and risk for AD until January 2012. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated using fixed and random effects models. Twenty-seven studies were included with a total of 19,135 individuals, involving 6,632 AD patients and 12,503 controls. For IL-6-174 G/C polymorphism, the combined results showed significant differences in recessive model (CC vs. CG+GG: OR = 0.65, 95%CI = 0.52–0.82). As regards IL-6-572 C/G polymorphism, significant associations were shown in dominant model (CG+GG vs. CC: OR = 0.73, 95% CI = 0.62–0.86) and in additive model (GG vs. CC, OR = 0.66, 95% CI = 0.46–0.96). In conclusion, genotype CC of IL-6-174 G/C and genotype GG plus GC of IL-6-572 C/G could decrease the risk of AD.

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0037858

DOI: 10.1371/journal.pone.0037858

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