Influence of Socioeconomic Status Trajectories on Innate Immune Responsiveness in Children

Meghan B Azad, Yuri Lissitsyn, Gregory E Miller, Allan B Becker, Kent T HayGlass and Anita L Kozyrskyj

PLOS ONE, 2012, vol. 7, issue 6, 1-9

Abstract: Objectives: Lower socioeconomic status (SES) is consistently associated with poor health, yet little is known about the biological mechanisms underlying this inequality. In children, we examined the impact of early-life SES trajectories on the intensity of global innate immune activation, recognizing that excessive activation can be a precursor to inflammation and chronic disease. Methods: Stimulated interleukin-6 production, a measure of immune responsiveness, was analyzed ex vivo for 267 Canadian schoolchildren from a 1995 birth cohort in Manitoba, Canada. Childhood SES trajectories were determined from parent-reported housing data using a longitudinal latent-class modeling technique. Multivariate regression was conducted with adjustment for potential confounders. Results: SES was inversely associated with innate immune responsiveness (p = 0.003), with persistently low-SES children exhibiting responses more than twice as intense as their high-SES counterparts. Despite initially lower SES, responses from children experiencing increasing SES trajectories throughout childhood were indistinguishable from high-SES children. Low-SES effects were strongest among overweight children (p

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0038669

DOI: 10.1371/journal.pone.0038669

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