Role of IKK/NF-κB Signaling in Extinction of Conditioned Place Aversion Memory in Rats

Cheng-Hao Yang, Xiang-Ming Liu, Ji-Jian Si, Hai-Shui Shi, Yan-Xue Xue, Jian-Feng Liu, Yi-Xiao Luo, Chen Chen, Peng Li, Jian-Li Yang, Ping Wu and Lin Lu

PLOS ONE, 2012, vol. 7, issue 6, 1-8

Abstract: The inhibitor κB protein kinase/nuclear factor κB (IKK/NF-κB) signaling pathway is critical for synaptic plasticity. However, the role of IKK/NF-κB in drug withdrawal-associated conditioned place aversion (CPA) memory is unknown. Here, we showed that inhibition of IKK/NF-κB by sulphasalazine (SSZ; 10 mM, i.c.v.) selectively blocked the extinction but not acquisition or expression of morphine-induced CPA in rats. The blockade of CPA extinction induced by SSZ was abolished by sodium butyrate, an inhibitor of histone deacetylase. Thus, the IKK/NF-κB signaling pathway might play a critical role in the extinction of morphine-induced CPA in rats and might be a potential pharmacotherapy target for opiate addiction.

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0039696

DOI: 10.1371/journal.pone.0039696

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