Mouse Allergen, Lung Function, and Atopy in Puerto Rican Children

Erick Forno, Michelle M Cloutier, Soma Datta, Kathryn Paul, Jody Sylvia, Deanna Calvert, Sherell Thornton-Thompson, Dorothy B Wakefield, John Brehm, Robert G Hamilton, María Alvarez, Angel Colón-Semidey, Edna Acosta-Pérez, Glorisa Canino and Juan C Celedón

PLOS ONE, 2012, vol. 7, issue 7, 1-9

Abstract: Objective: To examine the relation between mouse allergen exposure and asthma in Puerto Rican children. Methods: Mus m 1, Der p 1, Bla g 2, and Fel d 1 allergens were measured in dust samples from homes of Puerto Rican children with (cases) and without (controls) asthma in Hartford, CT (n = 449) and San Juan (SJ), Puerto Rico (n = 678). Linear or logistic regression was used for the multivariate analysis of mouse allergen (Mus m 1) and lung function (FEV1 and FEV1/FVC) and allergy (total IgE and skin test reactivity (STR) to ≥1 allergen) measures. Results: Homes in SJ had lower mouse allergen levels than those in Hartford. In multivariate analyses, mouse allergen was associated with higher FEV1 in cases in Hartford (+70.6 ml, 95% confidence interval (CI) = 8.6–132.7 ml, P = 0.03) and SJ (+45.1 ml, 95% CI = −0.5 to 90.6 ml, P = 0.05). In multivariate analyses of controls, mouse allergen was inversely associated with STR to ≥1 allergen in non-sensitized children (odds ratio [OR] for each log-unit increment in Mus m 1 = 0.7, 95% CI = 0.5–0.9, P

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0040383

DOI: 10.1371/journal.pone.0040383

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