Socioeconomic and Nutritional Factors Account for the Association of Gastric Cancer with Amerindian Ancestry in a Latin American Admixed Population

Latife Pereira, Roxana Zamudio, Giordano Soares-Souza, Phabiola Herrera, Lilia Cabrera, Catherine C Hooper, Jaime Cok, Juan M Combe, Gloria Vargas, William A Prado, Silvana Schneider, Fernanda Kehdy, Maira R Rodrigues, Stephen J Chanock, Douglas E Berg, Robert H Gilman and Eduardo Tarazona-Santos

PLOS ONE, 2012, vol. 7, issue 8, 1-8

Abstract: Gastric cancer is one of the most lethal types of cancer and its incidence varies worldwide, with the Andean region of South America showing high incidence rates. We evaluated the genetic structure of the population from Lima (Peru) and performed a case-control genetic association study to test the contribution of African, European, or Native American ancestry to risk for gastric cancer, controlling for the effect of non-genetic factors. A wide set of socioeconomic, dietary, and clinic information was collected for each participant in the study and ancestry was estimated based on 103 ancestry informative markers. Although the urban population from Lima is usually considered as mestizo (i.e., admixed from Africans, Europeans, and Native Americans), we observed a high fraction of Native American ancestry (78.4% for the cases and 74.6% for the controls) and a very low African ancestry (

Date: 2012
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041200 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 41200&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0041200

DOI: 10.1371/journal.pone.0041200

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().