Cytotoxic T-Lymphocyte Associated Antigen 4 Polymorphisms and Asthma Risk: A Meta-Analysis

Wei Nie, Jiquan Chen and Qingyu Xiu

PLOS ONE, 2012, vol. 7, issue 7, 1-10

Abstract: Background: A number of studies assessed the association of cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) gene polymorphisms with asthma in different populations. However, the results were contradictory. We performed a meta-analysis to examine the association between CTLA-4 polymorphisms and asthma susceptibility. Methods: Pubmed, EMBASE, HuGE Navigator, and Wanfang Database were searched. Data were extracted independently by two reviewers. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Results: Seventeen studies involving 6378 cases and 8674 controls were included. Significant association between +49 A/G polymorphism and asthma was observed for AA vs. AG+GG (OR = 1.18, 95% CI 1.01–1.37, P = 0.04). There were no significant associations between −318 C/T, −1147 C/T, CT60 A/G, −1722 C/T, or rs926169 polymorphisms and asthma risk. Conclusions: This meta-analysis suggested that the +49 A/G polymorphism in CTLA-4 was a risk factor for asthma.

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0042062

DOI: 10.1371/journal.pone.0042062

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