Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

Ramasamy, Adaikalavan; Kuokkanen, Mikko; Vedantam, Sailaja; Gajdos, Zofia K; Alves, Alexessander Couto; Lyon, Helen N; Ferreira, Manuel A R; Strachan, David P; Zhao, Jing Hua; Abramson, Michael J; Brown, Matthew A; Coin, Lachlan; Dharmage, Shyamali C; Duffy, David L; Haahtela, Tari; Heath, Andrew C; Janson, Christer; Kähönen, Mika; Khaw, Kay-Tee; Laitinen, Jaana; Souef, Peter Le; Lehtimäki, Terho; Collaborators, Australian Asthma Genetics Consortium; Madden, Pamela A F; Marks, Guy B; Martin, Nicholas G; Matheson, Melanie C; Palmer, Cameron D; Palotie, Aarno; Pouta, Anneli; Robertson, Colin F; Viikari, Jorma; Widen, Elisabeth; Wjst, Matthias; Jarvis, Deborah L; Montgomery, Grant W; Thompson, Philip J; Wareham, Nick; Eriksson, Johan; Jousilahti, Pekka; Laitinen, Tarja; Pekkanen, Juha; Raitakari, Olli T; O'Connor, George T; Salomaa, Veikko; Jarvelin, Marjo-Riitta; Hirschhorn, Joel N

Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

Adaikalavan Ramasamy, Mikko Kuokkanen, Sailaja Vedantam, Zofia K Gajdos, Alexessander Couto Alves, Helen N Lyon, Manuel A R Ferreira, David P Strachan, Jing Hua Zhao, Michael J Abramson, Matthew A Brown, Lachlan Coin, Shyamali C Dharmage, David L Duffy, Tari Haahtela, Andrew C Heath, Christer Janson, Mika Kähönen, Kay-Tee Khaw, Jaana Laitinen, Peter Le Souef, Terho Lehtimäki, Australian Asthma Genetics Consortium Collaborators, Pamela A F Madden, Guy B Marks, Nicholas G Martin, Melanie C Matheson, Cameron D Palmer, Aarno Palotie, Anneli Pouta, Colin F Robertson, Jorma Viikari, Elisabeth Widen, Matthias Wjst, Deborah L Jarvis, Grant W Montgomery, Philip J Thompson, Nick Wareham, Johan Eriksson, Pekka Jousilahti, Tarja Laitinen, Juha Pekkanen, Olli T Raitakari, George T O'Connor, Veikko Salomaa, Marjo-Riitta Jarvelin and Joel N Hirschhorn

PLOS ONE, 2012, vol. 7, issue 9, 1-10

Abstract: Rationale: Asthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies. Objectives: To test if population-based cohorts with self-reported physician-diagnosed asthma and genome-wide association (GWA) data could be used to validate known associations with asthma and identify novel associations. Methods: The APCAT (Analysis in Population-based Cohorts of Asthma Traits) consortium consists of 1,716 individuals with asthma and 16,888 healthy controls from six European-descent population-based cohorts. We examined associations in APCAT of thirteen variants previously reported as genome-wide significant (P

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0044008

DOI: 10.1371/journal.pone.0044008

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