Similar Pathogen Targets in Arabidopsis thaliana and Homo sapiens Protein Networks

Paulo Shakarian and J Kenneth Wickiser

PLOS ONE, 2012, vol. 7, issue 9, 1-7

Abstract: We study the behavior of pathogens on host protein networks for humans and Arabidopsis - noting striking similarities. Specifically, we preform -shell decomposition analysis on these networks - which groups the proteins into various “shells” based on network structure. We observe that shells with a higher average degree are more highly targeted (with a power-law relationship) and that highly targeted nodes lie in shells closer to the inner-core of the network. Additionally, we also note that the inner core of the network is significantly under-targeted. We show that these core proteins may have a role in intra-cellular communication and hypothesize that they are less attacked to ensure survival of the host. This may explain why certain high-degree proteins are not significantly attacked.

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0045154

DOI: 10.1371/journal.pone.0045154

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