Reproducibility and Respiratory Function Correlates of Exhaled Breath Fingerprint in Chronic Obstructive Pulmonary Disease

Raffaele Antonelli Incalzi, Giorgio Pennazza, Simone Scarlata, Marco Santonico, Massimo Petriaggi, Domenica Chiurco, Claudio Pedone, Arnaldo and D'Amico

PLOS ONE, 2012, vol. 7, issue 10, 1-8

Abstract: Background: The electronic nose (e nose) provides distinctive breath fingerprints for selected respiratory diseases. Both reproducibility and respiratory function correlates of breath fingerprint are poorly known. Objectives: To measure reproducibility of breath fingerprints and to assess their correlates among respiratory function indexes in elderly healthy and COPD subjects. Method: 25 subjects (5 COPD patients for each GOLD stage and 5 healthy controls) over 65 years underwent e-nose study through a seven sensor system and respiratory function tests at times 0, 7, and 15 days. Reproducibility of the e nose pattern was computed. The correlation between volatile organic compound (VOC) pattern and respiratory function/clinical parameters was assessed by the Spearman's rho. Measurements and Main Results: VOC patterns were highly reproducible within healthy and GOLD 4 COPD subjects, less among GOLD 1–3 patients.VOC patterns significantly correlated with expiratory flows (Spearman's rho ranging from 0.36 for MEF25% and sensor Co-Buti-TPP, to 0.81 for FEV1% and sensor Cu-Buti-TPP p

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0045396

DOI: 10.1371/journal.pone.0045396

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