Association Study of Gene LPP in Women with Polycystic Ovary Syndrome

Bo Zhang, Han Zhao, Tao Li, Xuan Gao, Qin Gao, Rong Tang, Jiangtao Zhang and Zi-Jiang Chen

PLOS ONE, 2012, vol. 7, issue 10, 1-4

Abstract: Background: Previous genome-wide association study (GWAS) of polycystic ovary syndrome (PCOS) in Han Chinese population has found that SNPs in LPP gene were nominally significant in PCOS patients (P around 10E-05). Replication of the GWAS was applied to further confirm the relationship between LPP gene and PCOS. Methods: Three polymorphisms of LPP gene (rs715790, rs4449306, rs6782041) were selected and replicated in additional 1132 PCOS cases and 1142 controls. Genotyping of LPP gene was carried out by Taqman-MGB method. Results: In rs715790, the allele frequency is significantly different between the PCOS group and the control group. Meta-analysis showed that the allele frequencies of the three SNPs rs715790 (Pmeta = 1.89E-05, OR = 1.23), rs4449306 (Pmeta = 3.0E-04, OR = 1.10), rs6782041 (Pmeta = 2.0E-04, OR = 1.09), were significantly different between PCOS cases and controls. Conclusions: Our results suggest that LPP gene might be a novel candidate for PCOS.

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0046370

DOI: 10.1371/journal.pone.0046370

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