Association of Genetic Variants Influencing Lipid Levels with Coronary Artery Disease in Japanese Individuals

Fumihiko Takeuchi, Masato Isono, Tomohiro Katsuya, Mitsuhiro Yokota, Ken Yamamoto, Toru Nabika, Kazuro Shimokawa, Eitaro Nakashima, Takao Sugiyama, Hiromi Rakugi, Shuhei Yamaguchi, Toshio Ogihara, Yukio Yamori and Norihiro Kato

PLOS ONE, 2012, vol. 7, issue 9, 1-9

Abstract: Background/Objective: In Japanese populations, we performed a replication study of genetic loci previously identified in European-descent populations as being associated with lipid levels and risk of coronary artery disease (CAD). Methods: We genotyped 48 single nucleotide polymorphisms (SNPs) from 22 candidate loci that had previously been identified by genome-wide association (GWA) meta-analyses for low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and/or triglycerides in Europeans. We selected 22 loci with 2 parallel tracks from 95 reported loci: 16 significant loci (p

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0046385

DOI: 10.1371/journal.pone.0046385

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