Periodontal Disease and Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Observational Studies

Xian-Tao Zeng, Ming-Li Tu, Dong-Yan Liu, Dong Zheng, Jing Zhang and WeiDong Leng

PLOS ONE, 2012, vol. 7, issue 10, 1-9

Abstract: Background: Many epidemiological studies have found a positive association between periodontal disease (PD) and risk of chronic obstructive pulmonary disease (COPD), but this association is varied and even contradictory among studies. We performed a meta-analysis to ascertain the relationship between PD and COPD. Methods: PubMed and Embase database were searched up to January 10, 2012, for relevant observational studies on the association between PD and risk of COPD. Data from the studies selected were extracted and analyzed independently by two authors. The meta-analysis was performed using the Comprehensive Meta-Analysis software. Results: Fourteen observational studies (one nested case-control, eight case-control, and five cross-sectional) involving 3,988 COPD patients were yielded. Based on random-effects meta-analysis, a significant association between PD and COPD was identified (odds ratio = 2.08, 95% confidence interval = 1.48–2.91; P

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0046508

DOI: 10.1371/journal.pone.0046508

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