Smoking, BCG and Employment and the Risk of Tuberculosis Infection in HIV-Infected Persons in South Africa

Tolu Oni, Hannah P Gideon, Nonzwakazi Bangani, Relebohile Tsekela, Ronnett Seldon, Kathryn Wood, Katalin A Wilkinson, Rene T Goliath, Tom H M Ottenhoff and Robert J Wilkinson

PLOS ONE, 2012, vol. 7, issue 10, 1-5

Abstract: Background: The increased susceptibility to latent tuberculosis infection (LTBI) of HIV-1-infected persons represents a challenge in TB epidemic control. However few studies have evaluated LTBI predictors in a generalized HIV/TB epidemic setting. Methods: The study recruited 335 HIV-infected participants from Khayelitsha, Cape Town between February 2008 and November 2010. Tuberculin skin tests and interferon-gamma release assays were performed on all participants and active TB excluded using a symptom screen, TB microscopy and culture. Results: LTBI prevalence was 52.7% and 61.2% (TST and IGRA respectively). Being a recent TB contact (OR 2.07; 95% C.I. 1.15–3.69) was associated with TST positivity. Participants with a CD4>200 had a two-fold higher risk of IGRA positivity compared to those with CD4 counts

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0047072

DOI: 10.1371/journal.pone.0047072

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