Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients

Ching-Wei Hsu, Ja-Liang Lin, Dan-Tzu Lin-Tan, Kuan-Hsing Chen, Tzung-Hai Yen, Mai-Szu Wu and Shih-Chieh Lin

PLOS ONE, 2012, vol. 7, issue 10, 1-9

Abstract: Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries. Although animal studies indicate that hemoperfusion (HP) within 2−4 h after intoxication effectively reduces mortality, the effect of early HP in humans remains unknown. Methods: We analyzed the records of all PQ-poisoned patients admitted to 2 hospitals between 2000 and 2009. Patients were grouped according to early or late HP and high-dose (oral cyclophosphamide [CP] and intravenous dexamethasone [DX]) or repeated pulse (intravenous methylprednisolone [MP] and CP, followed by DX and repeated MP and/or CP) PQ therapy. Early HP was defined as HP

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0048397

DOI: 10.1371/journal.pone.0048397

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