Genome-Wide Association Study Heterogeneous Cohort Homogenization via Subject Weight Knock-Down

André X C N Valente, Joseph Zischkau, Joo Heon Shin, Yuan Gao and Abhijit Sarkar

PLOS ONE, 2012, vol. 7, issue 10, 1-10

Abstract: Population structure can be a source of both false-positive and false-negative findings in a genome-wide association study. This article proposes an approach that helps to reduce the false-positives. It consists of homogenizing the diseased/healthy phenotype ratio across the cohort, by decreasing the statistical weight of selected individuals. After homogenization, the cohort is statistically handled as if originating from a single well-mixed population. The method was applied to homogenize a Parkinson's disease genome-wide association study cohort.

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0048653

DOI: 10.1371/journal.pone.0048653

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