Prospective Analysis of the Association of a Common Variant of FTO (rs9939609) with Adiposity in Children: Results of the IDEFICS Study

Fabio Lauria, Alfonso Siani, Karin Bammann, Ronja Foraita, Inge Huybrechts, Licia Iacoviello, Anna C Koni, Yannis Kourides, Staffan Marild, Denes Molnar, Luis A Moreno, Iris Pigeot, Yannis P Pitsiladis, Toomas Veidebaum, Paola Russo and Consortium Idefics

PLOS ONE, 2012, vol. 7, issue 11, 1-6

Abstract: Objectives: We investigated cross-sectionally and longitudinally the relationship between FTO rs9939609 and obesity-related characteristics in the European children of the IDEFICS project and the interaction of this variant with a lifestyle intervention. Population and Methods: A cohort of 16224 children (2–9 years) was recruited into a population-based survey (T0) from eight European countries. A second survey (T1) reassessed the children two years later. A random sample of 4405 children was extracted for genetic studies. 3168 children were re-examined two years later. Half of them underwent a lifestyle intervention program. The FTO rs9939609 was genotyped. Weight, height, waist circumference, triceps and subscapular skinfolds were measured at T0 and T1. Results: At T0, the risk A allele of rs9939609 was significantly associated with higher values of body mass index (BMI), waist circumference and skinfolds (age, sex, and country-adjusted p-values: all p

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0048876

DOI: 10.1371/journal.pone.0048876

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