Gamma-Glutamyltransferase Level and Risk of Hypertension: A Systematic Review and Meta-Analysis

Cun-Fei Liu, Yu-Ting Gu, Hai-Ya Wang and Ning-Yuan Fang

PLOS ONE, 2012, vol. 7, issue 11, 1-7

Abstract: Background: Several prospective observational studies suggest that gamma-glutamyltransferase(GGT) level is positively associated with risk of hypertension. However, these studies draw inconsistent conclusions. Therefore, we conducted a systematic review and meta-analysis to evaluate the exact association between GGT level and subsequent development of hypertension. Methods: We searched Pubmed, Embase, and Science Citation Index (ISI Web of Science) for prospective cohort studies examining the association between GGT level and hypertension. Then, pooled effect estimates (RRs) for the association between GGT level and hypertension were calculated. Results: A total of 13 prospective cohort studies including 43314 participants and 5280 cases of hypertension were included. The pooled RR of hypertension was 1.94(95%CI: 1.55–2.43; P

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0048878

DOI: 10.1371/journal.pone.0048878

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