Improvement of Left Ventricular Function under Cardiac Resynchronization Therapy Goes along with a Reduced Incidence of Ventricular Arrhythmia

Christian Eickholt, Marcus Siekiera, Kiriakos Kirmanoglou, Astrid Rodenbeck, Nicole Heussen, Patrick Schauerte, Artur Lichtenberg, Jan Balzer, Tienush Rassaf, Stefan Perings, Malte Kelm, Dong-In Shin and Christian Meyer

PLOS ONE, 2012, vol. 7, issue 11, 1-7

Abstract: Objectives: The beneficial effects of cardiac resynchronization therapy (CRT) are thought to result from favorable left ventricular (LV) reverse remodeling, however CRT is only successful in about 70% of patients. Whether response to CRT is associated with a decrease in ventricular arrhythmias (VA) is still discussed controversially. Therefore, we investigated the incidence of VA in CRT responders in comparison with non-responders. Methods: In this nonrandomized, two-center, observational study patients with moderate-to-severe heart failure, LV ejection fraction (LVEF) ≤35%, and QRS duration >120 ms undergoing CRT were included. After 6 months patients were classified as CRT responders or non-responders. Incidence of VA was compared between both groups by Kaplan-Meier analysis and Cox regression analysis. ROC analysis was performed to determine the aptitude of LVEF cut-off values to predict VA. Results: In total 126 consecutive patients (64±11years; 67%male) were included, 74 were classified as responders and 52 as non-responders. While the mean LVEF at baseline was comparable in both groups (25±7% vs. 24±8%; P = 0.4583) only the responder group showed an improvement of LVEF (36±6% vs. 24±7; p 7% was found to be a predictor of a significantly lower incidence of VA (AUC = 0.606). Conclusions: Improvement of left ventricular function under cardiac resynchronization therapy goes along with a reduced incidence of ventricular arrhythmia.

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0048926

DOI: 10.1371/journal.pone.0048926

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