Higher Blood 25(OH)D Level May Reduce the Breast Cancer Risk: Evidence from a Chinese Population Based Case-Control Study and Meta-Analysis of the Observational Studies

Peizhan Chen, Mian Li, Xiaoli Gu, Yanling Liu, Xiaoguang Li, Chenglin Li, Yuan Wang, Dong Xie, Fudi Wang, Chen Yu, Jingquan Li, Xinlei Chen, Ruiai Chu, Jianmin Zhu, Zhouluo Ou and Hui Wang

PLOS ONE, 2013, vol. 8, issue 1, 1-10

Abstract: Experimental data suggest a protective effect of vitamin D on breast cancer; however, epidemiologic results remain inclusive. With a Chinese population-based case-control study and meta-analysis of the observational studies, we here systematically evaluated the association of blood 25(OH)D level and breast cancer risk. With 593 breast cancer cases and 580 cancer-free controls from Shanghai, China, we found that 80% of the normal women had severe vitamin D deficiency (less than 20 ng/mL) and 15.2% had mild deficiency (20 to 30 ng/mL) and only 4.8% of women had sufficient vitamin D level (>30 ng/mL) while the proportion was 96.1%, 3.2% and 0.7% respectively for the breast cancer patients. Compared to those with the lowest quartile of plasma 25(OH)D level, women with highest quartile 25(OH)D level showed a significant decreased breast cancer risk (Q4 vs.Q1: OR = 0.10, 95% CI = 0.06–0.15) and every 1 ng/ml increment of plasma 25(OH)D level led to a 16% lower odds of breast cancer (OR = 0.84, 95% CI = 0.81–0.87; P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0049312

DOI: 10.1371/journal.pone.0049312

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