Beat-to-Beat Vectorcardiographic Analysis of Ventricular Depolarization and Repolarization in Myocardial Infarction

Muhammad A Hasan, Derek Abbott and Mathias Baumert

PLOS ONE, 2012, vol. 7, issue 11, 1-10

Abstract: Objectives: Increased beat-to-beat variability in the QT interval has been associated with heart disease and mortality. The purpose of this study was to investigate the beat-to-beat spatial and temporal variations of ventricular depolarization and repolarization in vectorcardiogram (VCG) for characterising myocardial infarction (MI) patients. Methods: Standard 12-lead ECGs of 84 MI patients (22 f, 63±12 yrs; 62 m, 56±10 yrs) and 69 healthy subjects (17 f, 42±18 yrs; 52 m, 40±13 yrs) were investigated. To extract the beat-to-beat QT intervals, a template-matching algorithm and the singular value decomposition method have been applied to synthesise the ECG data to VCG. Spatial and temporal variations in the QRS complex and T-wave loops were studied by investigating several descriptors (point-to-point distance variability, mean loop length, T-wave morphology dispersion, percentage of loop area, total cosine R-to-T). Results: Point-to-point distance variability of QRS and T-loops (0.13±0.04 vs. 0.10±0.04, p

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0049489

DOI: 10.1371/journal.pone.0049489

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