Association between Leukocyte and Metabolic Syndrome in Urban Han Chinese: A Longitudinal Cohort Study

Wenjia Meng, Chengqi Zhang, Qian Zhang, Xinhong Song, Haiyan Lin, Dongzhi Zhang, Yongyuan Zhang, Zhenxin Zhu, Shuo Wu, Yanxun Liu, Fang Tang, Xiaowei Yang and Fuzhong Xue

PLOS ONE, 2012, vol. 7, issue 11, 1-7

Abstract: Background: Although cross-sectional studies have shown that leukocyte is linked with metabolic syndrome (MetS), few longitudinal or cohort studies have been used to confirm this relationship. We therefore conducted a large-scale health check-up longitudinal cohort in urban Chinese population from middle to upper socioeconomic strata to investigate and prove the association between the total leukocyte/its subtypes and MetS/its components (obesity, hyperglycemia, dyslipidemia, and hypertension). Methods: A longitudinal cohort study was established in 2005 on individuals who were middle-to-upper class urban Chinese. Data used in this investigation was based on 6,513 participants who had at least three routine health check-ups over a period of six-year follow-up. Data analysis was conducted through generalized estimating equation (GEE) model. Results: A total of 255 cases of MetS occurred over the six-year follow-up, leading to a total incidence density of 11.45 per 1,000 person-years (255/22279 person-years). The total leukocyte was markedly associated with MetS (RR = 2.66, 95%CI = 1.81–3.90], p

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0049875

DOI: 10.1371/journal.pone.0049875

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