Hsa-miR-499 rs3746444 Polymorphism Contributes to Cancer Risk: A Meta-Analysis of 12 Studies

Man-Tang Qiu, Jing-Wen Hu, Xiang-Xiang Ding, Xin Yang, Zhi Zhang, Rong Yin and Lin Xu

PLOS ONE, 2012, vol. 7, issue 12, 1-7

Abstract: Background: Single nucleotide polymorphisms (SNPs) occurred in pre-microRNAs or targets of microRNAs (miRs) may contribute to cancer risks. Since 2007, many studies have investigated the association between common SNPs located on hsa-miR-499 (rs3746444) and cancer risks; however, the results were inconclusive. Methodology/Principal Findings: We conducted a meta-analysis of 12 studies that included 5765 cases and 7076 controls to identify the strength of association. Odds ratio (OR) and 95% confidence intervals (95% CI) were used to assess the strength of association. Overall, individuals with the variant AG (OR = 1.215, 95% CI: 1.027, 1.437; Pheterogeneity

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0050887

DOI: 10.1371/journal.pone.0050887

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